Keywords :
1)Uvaria micrantha 2)Annonaceae 3)benzoquinone 4) cytotoxicity 5) uvarmicranone
บทคัดย่อ :
Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3-17) were isolated from the stems
of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated com-
pounds were evaluated for their cytotoxic activities. Compounds 1, 14, and 15 showed moderate cytotoxic effects against T-cell
acute lymphoblastic cells (MOLT-3), with IC50 values of 7.83
เอกสารอ้างอิง :
Boonsombat, J., Thongnest, S., Kheawchaum, S., Mahidol, C., Ruchirawat, S., & Prawat, H. (2021). Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson. Natural Product Research, 35(24), 5643-5652.
