Keywords :
Uvaria micrantha; Annonaceae; Benzoquinone; Cytotoxicity; Uvarmicranone
บทคัดย่อ :
Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3-17) were isolated from the stems
of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cycloaddition reaction was also proposed. Some isolated compounds were evaluated for their cytotoxic activities. Compounds 1, 14, and 15 showed moderate cytotoxic effects against T-cell acute lymphoblastic cells (MOLT-3), with IC50 values of 7.83 (+-) 0.83, 6.53 (+-) 1.01, and 4.20 (+-) 0.29 lM, respectively. Additionally, compound 15 exhibited moderate cytotoxicity against cervical carcinoma cells (HeLa) with an IC50 value of 7.00 (+-) 3.15 lM.
เอกสารอ้างอิง :
Boonsombat, J., Thongnest, S., Kheawchaum, S., Mahidol, C., Ruchirawat, S., & Prawat, H. (2021). Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson. Natural Product Research, 35(24), 5643-5652.
